Frank Porreca Selected Research

Ondansetron (Zofran)

8/2013	Descending facilitation maintains long-term spontaneous neuropathic pain.
1/2012	Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.
7/2011	Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.
6/2011	Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats.
7/2009	Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors.
5/2007	Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.

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Frank Porreca Research Topics

Disease

142	Pain (Aches) 05/2024 - 09/2001
85	Hyperalgesia 01/2024 - 05/2002
60	Neuralgia (Stump Neuralgia) 04/2024 - 01/2002
55	Hypersensitivity (Allergy) 05/2024 - 06/2002
43	Chronic Pain 09/2023 - 06/2003
38	Migraine Disorders (Migraine) 04/2024 - 02/2009
14	Inflammation (Inflammations) 01/2021 - 10/2003
13	Headache (Headaches) 03/2024 - 10/2008
10	Neoplasms (Cancer) 05/2024 - 01/2005
10	Secondary Headache Disorders 01/2022 - 03/2010
5	Parkinson Disease (Parkinson's Disease) 12/2023 - 09/2011
5	Acute Pain 04/2019 - 05/2006
4	Brain Concussion (Cerebral Concussion) 11/2023 - 12/2019
4	Nervous System Diseases (Neurological Disorders) 01/2022 - 08/2010
4	Peripheral Nerve Injuries 10/2020 - 05/2002
4	Pancreatitis 01/2019 - 06/2006
4	Cancer Pain 10/2015 - 06/2003
4	Tics (Tic) 07/2013 - 02/2003
3	Dyskinesias (Dyskinesia) 12/2023 - 10/2018
3	Post-Traumatic Headache 10/2022 - 12/2019
3	Wounds and Injuries (Trauma) 01/2020 - 06/2003
3	Visceral Pain 01/2019 - 10/2008
3	Breast Neoplasms (Breast Cancer) 01/2018 - 10/2011
3	Bone Neoplasms (Bone Cancer) 01/2018 - 11/2007

Drug/Important Bio-Agent (IBA)

62	Opioid Analgesics (Opioids)IBA 09/2023 - 08/2002
32	Dynorphins (Dynorphin)IBA 04/2024 - 06/2002
31	Morphine (MS Contin)FDA LinkGeneric 09/2023 - 08/2002
29	Analgesics (Analgesic Drugs)IBA 11/2021 - 02/2003
22	LigandsIBA 12/2023 - 06/2004
15	Opioid Receptors (Opioid Receptor)IBA 02/2024 - 06/2004
15	Lidocaine (Xylocaine)FDA LinkGeneric 11/2021 - 06/2002
14	kappa Opioid Receptors (kappa Opioid Receptor)IBA 04/2024 - 12/2016
13	Dopamine (Intropin)FDA LinkGeneric 12/2023 - 12/2012
13	Opiate AlkaloidsIBA 01/2017 - 01/2005
12	salicylhydroxamic acid (SHAM)IBA 04/2024 - 09/2003
11	Sumatriptan (Imigran)FDA LinkGeneric 01/2022 - 10/2008
10	Calcitonin Gene-Related PeptideIBA 04/2024 - 02/2009
10	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2020 - 01/2011
10	Bradykinin Receptors (Bradykinin Receptor)IBA 12/2016 - 12/2006
9	Proteins (Proteins, Gene)FDA Link 05/2024 - 08/2007
9	Peptides (Polypeptides)IBA 12/2023 - 01/2007
8	mu Opioid Receptors (mu Opioid Receptor)IBA 09/2023 - 06/2002
8	Capsaicin (Zostrix)FDA Link 01/2019 - 10/2003
7	ProlactinIBA 04/2024 - 01/2020
7	norbinaltorphimineIBA 02/2024 - 07/2017
7	Ion Channels (Ion Channel)IBA 10/2020 - 06/2004
6	Calcitonin Gene-Related Peptide Receptor AntagonistsIBA 04/2024 - 01/2020
6	(1R,5S)- 4- methyl- 1- propan- 2- ylbicyclo(3.1.0)hex- 3- en- 2- oneIBA 01/2024 - 02/2012
6	Gabapentin (Neurontin)FDA LinkGeneric 11/2021 - 08/2014
6	Freund's AdjuvantIBA 12/2016 - 04/2005
6	Clonidine (ST 155)FDA LinkGeneric 05/2015 - 06/2004
6	Ondansetron (Zofran)FDA LinkGeneric 08/2013 - 05/2007
6	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2013 - 12/2002
6	Tryptamines (Triptans)IBA 04/2012 - 10/2008
5	Opioid Peptides (Opioid Peptide)IBA 12/2023 - 02/2003
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2012
5	Serotonin (5 Hydroxytryptamine)IBA 11/2019 - 01/2012
5	Substance PIBA 01/2019 - 08/2010
5	Cholecystokinin (Pancreozymin)IBA 01/2012 - 01/2005
5	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 06/2011 - 01/2005
4	Semaphorin-3AIBA 05/2024 - 01/2016
4	Neurotransmitter Agents (Neurotransmitter)IBA 04/2024 - 12/2005
4	Levodopa (L Dopa)FDA LinkGeneric 12/2023 - 10/2018
4	Prolactin Receptors (Prolactin Receptor)IBA 07/2023 - 01/2020
4	Monoclonal AntibodiesIBA 01/2023 - 12/2019
4	Protein Isoforms (Isoforms)IBA 01/2022 - 01/2003
4	EnkephalinsIBA 12/2021 - 11/2007
4	CytokinesIBA 01/2021 - 06/2004
4	BradykininIBA 10/2020 - 12/2006
4	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2019 - 04/2012
4	dibutyldichlorotinIBA 01/2019 - 10/2008
4	Dizocilpine Maleate (Dizocilpine)IBA 10/2018 - 11/2002
4	dermorphin-saporinIBA 01/2016 - 06/2002
4	Cholecystokinin B ReceptorIBA 08/2013 - 01/2005
4	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 09/2012 - 08/2010
4	CarrageenanIBA 08/2012 - 10/2003
4	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 09/2011 - 08/2005
4	Sodium Channels (Sodium Channel)IBA 05/2006 - 01/2002
3	AntibodiesIBA 03/2024 - 05/2017
3	Narcotic Antagonists (Opioid Antagonists)IBA 02/2024 - 04/2013
3	Messenger RNA (mRNA)IBA 12/2023 - 11/2010
3	Naloxone (Narcan)FDA LinkGeneric 07/2021 - 11/2007
3	NeuropeptidesIBA 01/2020 - 01/2005
3	Cannabinoid Receptor AgonistsIBA 01/2020 - 02/2003
3	CannabinoidsIBA 01/2020 - 09/2001
3	Nitric Oxide DonorsIBA 01/2020 - 03/2010
3	Nerve Growth Factors (Neurotrophins)IBA 01/2019 - 06/2003
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2018 - 06/2004
3	Interleukin-6 (Interleukin 6)IBA 01/2018 - 11/2010
3	Lacosamide FDA Link 12/2017 - 01/2016
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/2016 - 06/2004
3	Calcium Channels (Calcium Channel)IBA 01/2016 - 04/2011
3	SaporinsIBA 01/2016 - 05/2007

Therapy/Procedure

52	Therapeutics 04/2024 - 05/2002
40	Ligation 09/2023 - 05/2002
6	Oral Administration 01/2020 - 03/2009
6	Spinal Injections 02/2014 - 06/2004
6	Analgesia 01/2013 - 10/2006
3	Diffuse Noxious Inhibitory Control 01/2021 - 01/2019
3	Drug Therapy (Chemotherapy) 01/2019 - 10/2005